Section Editor
Jemi Olak, MD

Stage I

1. A Phase III study of adjuvant chemotherapy after resection of Stage 1(T2N0M0) non-small cell lung cancer
2. VATS lobectomy: A feasibility study
   

   Stage I + II

3. Phase II prospective randomized study of adjuvant chemotherapy in completely resected Stage I (T2N0M0) and II non-small cell lung cancer with a companion tumor marker evaluation (BR10)
   
4. Randomized trial of mediastinal lymph node sampling versus complete lymphadenectomy during pulmonary resection in the patient with N0 or N1 (less than hilar) non-small cell carcinoma
   
   
5. The utility of PET in staging of patients with potentially operable non-small cell lung carcinoma
   
6. Phase I study of decitabine-mediated induction of tumor antigen and tumor suppressor gene expression in lung cancer patients
   

   Stage II + IIIa

7. A phase III comparison between concurrent chemotherapy plus radiotherapy, and concurrent chemotherapy plus radiotherapy followed by surgical resection for stage IIIa (N2) non-small cell lung cancer
   
8. Pre-resection minimally invasive surgical restaging of Stage III (mediastinal node positive) non-small cell lung cancer
9. A prospective study of the prognostic significance of occult metastases in the patient with resectable non-small cell lung carcinoma
   

   Stage Ib,II, IIIa

10. Intergroup S9900: A Randomized Phase III trial of preoperative chemotherapy (paclitaxel + carboplatin) + surgery versus surgery alone in patients with early stage or resectable NSCLC

    Metastatic Disease

11. Phase I study of isolated lung perfusion with paclitazel and moderate hyperthermia in patients with unresectable pulmonary malignancies
    

    Esophageal Cancer

12. no active trials at present

Stage I

1. Phase III double-blind randomized trial of 13-cis retinoic acid (13-CRA) to prevent second primary tumors in Stage I non-small cell lung cancer
   Video assisted wedge resection (VAR) and radiotherapy for high risk T1 non-small cell lung cancer: A phase II study
   

   Stage II + IIIa

   Prospective randomized trial of postoperative adjuvant therapy in patients with completely resected stage II and stage IIIa non-small cell lung cancer
   
   Phase III trial of surgical resection and chemotherapy (carboplatin and taxol) with or without adjuvant radiotherapy for mediastinoscopy negative but thoracotomy positive N2 Stage IIIa non-small cell lung cancer
   
   Phase II intergroup trial for superior sulcus lung cancer(Pancoast tumor) with concurrent chemo-radiation as induction therapy
   

   Metastatic Disease & Malignant Pleural Effusion

   Sclerosis of pleural effusions by talc thoracoscopy versus talc slurry: A Phase III Study
   A prospective randomized trial of Bleomycin vs Doxycycline vs Talc for intrapleural treatment of malignant pleural effusion
   
   Randomized trial of Open vs VATS for pulmonary metastasis
   

   Thymoma

   
   
   Phase II Study of VIP (Etoposide, Ifosfamide and Cisplatin)in the Treatment of Invasive Thymoma

   Esophageal Cancer

   Thoracoscopic staging for esophageal cancer
   A prospective randomized phase III trial comparing trimodality therapy to surgery alone for esophageal cancer

1. Multicenter randomized clinical trial on Lung Volume Reduction Surgery
2. Canadian Lung Volume Reduction Study