Previous Studies

 

Previous CHSS Studies
These studies have been closed for new enrollment
but we continue to follow these patients
Transposition of the Great Arteries (TGA) Study

Objectives:

  • To assemble a multi-institutional inception cohort of neonates with Transposition of the Great Arteries
  • To compare survival outcomes of neonates age 2 weeks presenting with various forms of TGA
From 1985 to 1989, 895 neonates with transposition of the great arteries were enrolled from 23 institutions.
 
Interrupted Aortic Arch (IAA) Study

Objectives:

  • To determine outcomes for neonates with interruption of the aortic arch (IAA)
  • To determine what patient management variables improve outcomes
From 1987 to 1997, 474 neonates were enrolled prospectively from 33 institutions.
 
Coarctation Study

Objectives:

  • To determine outcomes for neonates with coarctation of the aorta
  • To analyze the importance of different treatment strategies
From 1990 to 1993, 965 neonates were enrolled prospectively from 32 institutions.
 
Pulmonary Atresia Intact Ventricular Septum (PAIVS) Study

Objectives:

  • Determine the proportion of neonates reaching defined end-states (i.e. Bi-ventricular Repair, Fontan, Heart Transplant, One-and-a-half ventricle repair or death)
  • Identify risk factors associated with end-state, including Bi-ventricular Repair Fontan, Heart Transplant, One-and-a-half ventricle repair or death
From January 1987 to April 1997, 408 neonates with PAIVS admitted to a CHSS institution within 30 days after birth were prospectively enrolled in a multi-institutional study.  PAIVS was defined as no communication between the right ventricle (RV) and pulmonary trunk and absence of ventricular septal defect (VSD) as determined by echocardiographic, catheterization, or surgical findings.
 
Pulmonary Stenosis with Intact Ventricular Septum (PSIVS) Cohort

Objectives:

  • To determine outcomes and associated patient and management factors for neonates with pulmonary stenosis with intact ventricular septum
  • To observe the transition from surgical to percutaneous management
From 1987 to 1993, 193 neonates were enrolled prospectively from 27 institutions.
 
Aortic Valve Atresia (AVA) and Aortic Valve Stenosis (AVS) Cohorts

Inclusion Criteria

  • Neonates younger than 30 days at the time of admission
  • First procedure at a CHSS member institution
  • Concordant atrioventricular and ventriculoarterial connections and either Aortic Valve Atresia (AVA) or critical Aortic Valve Stenosis (AVS)
  • AVA is defined as the absence of blood flow across the aortic valve, as determined by color Doppler echocardiography
  • AVS is critically important left ventricular outflow tract obstruction or hypoplasia, with demonstrated patency of the aortic valve and either moderately or severely reduced left ventricular function at admission or presence of duct-dependent systemic perfusion
Exclusion Criteria
  • First procedure at a non-CHSS institution
  • Age >30 days at the time of admission
  • Atrioventricular or ventriculoarterial discordance
  • Any AVA or AVS that does not meet the morphologic criteria
Pulmonary Conduit (PC) Study

Objectives:

  • Assemble a multi-institutional inception cohort of infants less than 2 years of age having pulmonary ventricle-pulmonary artery
  • Conduit placement
  • Determine the best conduit for infants and young children
  • Determine optimal conduit for replacement of previous conduits
Inclusion Criteria
  • Valved Conduit implant at age <2 years at member institution
  • Date of first implant AFTER January 1, 2002
  • Note: Patients who have 1.5 ventricle repair (e.g. CCTGA) are included
  • Survival to hospital discharge after conduit insertion
  • First pulmonary ventricle-pulmonary artery conduit placement
  • Informed consent from parents/guardian

Exclusion Criteria

  • Single Ventricle RV-PA conduit, e.g. Norwood RV-PA conduit
  • Non-Valved Conduit
  • VSD Fenestrated or not closed